Ten years ago, Neo Tokyo was suddenly infested by killer mecha. Today, the machines are haunted by high-tech bounty hunters known as 'Wreckers' in the city's Sector-K district - now rebranded as 'Killtopia,' and home to the world's most popular bloodsport.
While on a hunt, an amateur and unlicensed Wrecker, Shinji, encounters Crash: the world's first sentient mecha. In Crash's code lies the cure to the Rot - a nanomachine plague that's slowly killing humanity, including Shinji's only remaining - his sister, Omi.
Together they set off to heal the planet, being pursued by only every Wrecker, yakuza ganga, android assassin, influencer, and scumbag in Neo Tokyo.