Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, “Randomization in Clinical Trials: Theory and Practice”, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. “Randomization in Clinical Trials: Theory and Practice”, Second Edition features: • Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials • A new chapter on covariate-adaptive randomization, including minimization techniques and inference • New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests • Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers' understanding “Randomization in Clinical Trials: Theory and Practice”, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics.
